Agenesis of the vena cava

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Agenesis of the vena cava is a genetic defect of the inferior vena cava. It comes about when, during development of the foetus, the right subcardinal vein does not connect as it should to the hepatic sinusoids.[1][2]:628.

Agenesis of the superior vena cava may also occur; it is very rare.[3]


  1. ^ Ben Pansky (1982). Chapter 126. Development of The Venous System: The Inferior Vena Cava. In Review of Medical Embryology. New York: Macmillan; London: Collier Macmillan.
  2. ^ Elliot L. Chaikof, Richard P. Cambria (2014). Atlas of Vascular Surgery and Endovascular Therapy. Philadelphia: Elsevier Health Sciences. ISBN 9781455759408.
  3. ^ De Souza, Valter Romão; Lemos, Victor Moreira Valença de; Lafayette, Daniell de Siqueira Araújo; Lemos, Roberto Souza de; Fontes, Luciana de Barros Correia; Lima, Glaydes Maria Torres de; Correia, Cláudia Wanderley de Barros; Domingues, Ana Lucia Coutinho; Aroucha, Amanda Queiroz da Mota Silveira (June 2018). "The first reported case of factor V Leiden mutation with agenesis of superior vena cava". Medicine. 97 (22): e10511. doi:10.1097/md.0000000000010511. ISSN 0025-7974. PMC 6392798. PMID 29851773.